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Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

《医学前沿（英文）》 2010年 第4卷 第3期   页码 280-284 doi: 10.1007/s11684-010-0098-2

摘要： Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy. The pathogenesis of PCOS is associated with both heredity and environment. PCOS has adverse impacts on female endocrine, reproduction, and metabolism. PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss. PCOS has additional metabolic derangements, such as insulin resistance, impaired glucose tolerance, and dyslipidemia. The risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased as well.

关键词： polycystic ovary syndrome     genetics     metabolic disturbance    

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Modal disturbance investigation of rod-shaped ultrasonic motor using bending vibrations

ZHANG Jiantao, ZHU Hua, ZHAO Chunsheng

《机械工程前沿（英文）》 2008年 第3卷 第3期   页码 343-347 doi: 10.1007/s11465-008-0058-6

摘要： Modal disturbance of a rod-shaped ultrasonic motor using bending vibrations can cause problems such as low motor efficiency, instability, and poor control. In this paper, a dynamic analysis model of a stator is created on the basis of the finite element method (FEM) and Hamilton principle. The modal frequency sensitivities of the stator to the structure parameters are investigated by modal analysis. Accordingly, the structure parameters of the stator are modified to separate working modes from disturbance modes. A rod-shaped ultrasonic motor stator is fabricated, and the experimental results of its amplitude frequency response characteristics show that the purpose of modal separation is achieved. The frequency separation between working modes and disturbance modes is more than 2 kHz. The validity of the method is verified.

关键词： Hamilton principle     disturbance     separation     frequency separation     dynamic analysis    

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New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1527-6

摘要：

• The promoting effects for VFA generation follow the order of APG>SDBS>HTAB.

关键词： Waste activated sludge (WAS)     Volatile fatty acids (VFA)     Surfactant types     Functional microorganisms     Metabolic activity upregulation    

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Metabolic hypertension: concept and practice

null

《医学前沿（英文）》 2013年 第7卷 第2期   页码 201-206 doi: 10.1007/s11684-013-0264-4

摘要：

Hypertension is a serious public health problem worldwide. More than 60% of the risk factors for hypertension are associated with metabolic disturbances. Metabolic abnormalities increase the risk for hypertension and cause high blood pressure. Improving metabolic disturbances is beneficial for hypertension treatment. Due to the importance of metabolic abnormalities in the pathogenesis of hypertension, we propose a concept of metabolic hypertension. In this review, we discuss and review the clinical types, pathogenesis, risk evaluation and management of metabolic hypertension. Elucidation of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.

关键词： hypertension     cardiometabolic risk factors     metabolic abnormalities    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 139-145 doi: 10.1007/s11684-015-0377-z

摘要：

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.

关键词： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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electron transfer and its application in dictating routes of biochemical processes associated with metabolic

《医学前沿（英文）》 2021年 第15卷 第5期   页码 679-692 doi: 10.1007/s11684-021-0866-1

摘要： Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in proliferating cancer cells, but the underneath rationale has remained to be elucidated. Based on the concept of the degree of reduction of a compound, we have recently proposed a calculation termed as potential of electron transfer (PET), which is used to characterize the degree of electron redistribution coupled with metabolic transformations. When this calculation is combined with the assumed model of electron balance in a cellular context, the enforced selective reprogramming could be predicted by examining the net changes of the PET values associated with the biochemical pathways in anaerobic metabolism. Some interesting properties of PET in cancer cells were also discussed, and the model was extended to uncover the chemical nature underlying aerobic glycolysis that essentially results from energy requirement and electron balance. Enabling electron transfer could drive metabolic reprogramming in cancer metabolism. Therefore, the concept and model established on electron transfer could guide the treatment strategies of tumors and future studies on cellular metabolism.

关键词： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer metabolism    

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Virtual reality system of manned maneuvering unit taking into consideration the disturbance from an astronaut

CHENG Jian, FAN Xiu-min, XU An, HONG Xin, HUANG Wei-dong

《机械工程前沿（英文）》 2006年 第1卷 第3期   页码 282-287 doi: 10.1007/s11465-006-0042-y

摘要： This paper describes a manned maneuvering unit (MMU) virtual reality system. Based on the dynamics/kinematics model of an astronaut equipped with an MMU, a disturbance model of the astronaut s arms under zero gravity conditions is developed. After measuring three initial-position information, the astronaut s arms tracking information is inputted by some tracker setting on an operator using real-time emendation and correction. Finally, the paper presents two different results between loading and unloading the disturbance model within the progress of simulation. From the different results, we find that the motion of an astronaut s arms has greater influence over space walking with the same control mode. The MMU virtual reality provides a new method for the simulation of real space walking, and also a perfect method for developing prototype MMU.

关键词： real-time emendation     disturbance     maneuvering     MMU     correction    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Application of a Novel Fuzzy Clustering Method Based on Chaos Immune Evolutionary Algorithm for Edge Detection in Image Processing

《机械工程前沿（英文）》 2006年 第1卷 第1期   页码 85-89 doi: 10.1007/s11465-005-0023-6

摘要：

A novel fuzzy clustering method based on chaos immune evolutionary algorithm (CIEFCM) is presented to solve fuzzy edge detection problems in image processing. In CIEFCM, a tiny disturbance is added to a filial generation group using a chaos variable and the disturbance amplitude is adjusted step by step, which greatly improves the colony diversity of the immune evolution algorithm (IEA). The experimental results show that the method not only can correctly detect the fuzzy edge and exiguous edge but can evidently improve the searching efficiency of fuzzy clustering algorithm based on IEA.

关键词： disturbance amplitude     disturbance     diversity     generation     processing    

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Metformin and metabolic diseases: a focus on hepatic aspects

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 173-186 doi: 10.1007/s11684-015-0384-0

摘要：

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

关键词： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1433-3

摘要：

• Short-term effect of the pyridine exposure on the SAD process was investigated.

关键词： Anammox     Inhibition     Metabolic pathway     Microbial community     Pyridine     SAD    

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Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1548-1

摘要：

• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.

关键词： Nano-toxicity     Nano-plastics     Quantum dots     Microbial metabolite     Metabolic dysregulation    

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The FGF metabolic axis

Xiaokun Li

《医学前沿（英文）》 2019年 第13卷 第5期   页码 511-530 doi: 10.1007/s11684-019-0711-y

摘要： Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional divergence and specification. Heparan sulfate-binding FGFs, which play critical roles in embryonic development and adult tissue remodeling homeostasis, adapt to an autocrine/paracrine mode of action to promote cell proliferation and population growth. By contrast, FGF19, 21, and 23 coevolve through losing binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane α-Klotho (KL) or β-KL as a coreceptor, thereby adapting to an endocrine mode of action to drive interorgan crosstalk that regulates a broad spectrum of metabolic homeostasis. FGF19 metabolic axis from the ileum to liver negatively controls diurnal bile acid biosynthesis. FGF21 metabolic axes play multifaceted roles in controlling the homeostasis of lipid, glucose, and energy metabolism. FGF23 axes from the bone to kidney and parathyroid regulate metabolic homeostasis of phosphate, calcium, vitamin D, and parathyroid hormone that are important for bone health and systemic mineral balance. The significant divergence in structural elements and multiple functional specifications of FGF19, 21, and 23 in cellular and organismal metabolism instead of cell proliferation and growth sufficiently necessitate a new unified and specific term for these three endocrine FGFs. Thus, the term “FGF Metabolic Axis,” which distinguishes the unique pathways and functions of endocrine FGFs from other autocrine/paracrine mitogenic FGFs, is coined.

关键词： FGF19     FGF21     FGF23     FGFR     metabolism     endocrine     Klotho    

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针对主动磁悬浮轴承干扰抑制的一类结合迭代学习控制与干扰观测器的解决方法 None

Ze-zhi TANG, Yuan-jin YU, Zhen-hong LI, Zheng-tao DING

《信息与电子工程前沿（英文）》 2019年 第20卷 第1期   页码 131-140 doi: 10.1631/FITEE.1800558

摘要： 针对主动磁悬浮轴承系统，传统迭代学习控制可实现高精度轨迹跟踪，但系统扰动必须限定为不随迭代变化。基于目前方法，提出一种抑制主动磁悬浮轴承系统中随迭代变化的不匹配扰动方法。在该方案中，结合经典迭代学习控制和普适性扩张观测器，在使用输出反馈信息情况下，可在每次迭代过程中估计并抑制外界变化干扰。分析证明了整个闭环系统的收敛性，同时，仿真结果表明，相比传统迭代学习控制，该控制方法轨迹跟踪性能更加优良。

关键词： 主动磁悬浮轴承；迭代学习控制；干扰观测器    

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Regulation of T cell immunity by cellular metabolism

null

《医学前沿（英文）》 2018年 第12卷 第4期   页码 463-472 doi: 10.1007/s11684-018-0668-2

摘要：

T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.

关键词： T cell immunity     metabolic pathways     nutrient uptake     metabolic checkpoints    

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标题 作者 时间 类型 操作

Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

期刊论文

Modal disturbance investigation of rod-shaped ultrasonic motor using bending vibrations

ZHANG Jiantao, ZHU Hua, ZHAO Chunsheng

期刊论文

New insights into different surfactants’ impacts on sludge fermentation: Focusing on the particular metabolic

期刊论文

Metabolic hypertension: concept and practice

null

期刊论文

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

null

期刊论文

electron transfer and its application in dictating routes of biochemical processes associated with metabolic

期刊论文

Virtual reality system of manned maneuvering unit taking into consideration the disturbance from an astronaut

CHENG Jian, FAN Xiu-min, XU An, HONG Xin, HUANG Wei-dong

期刊论文

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

期刊论文

Application of a Novel Fuzzy Clustering Method Based on Chaos Immune Evolutionary Algorithm for Edge Detection in Image Processing

期刊论文

Metformin and metabolic diseases: a focus on hepatic aspects

null

期刊论文

denitrification system with short-term pyridine exposure: Process capability, inhibition kinetics and metabolic

期刊论文

Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

期刊论文

The FGF metabolic axis

Xiaokun Li

期刊论文

针对主动磁悬浮轴承干扰抑制的一类结合迭代学习控制与干扰观测器的解决方法

Ze-zhi TANG, Yuan-jin YU, Zhen-hong LI, Zheng-tao DING

期刊论文

Regulation of T cell immunity by cellular metabolism

null

期刊论文